There are different mechanisms for lipid antigen uptake depending upon the antigen source and its structure such that endogenous lipids are differentially distributed in subcellular compartments and internalized lipids are transported to different endocytotic vesicles. With concomitant degradation of myelin, oligodendrocytes and axons, along with reactive astrogliosis and activated microglia - meaning that there is no only the problem of demzeliniyation but of hzperactive microglia.Īdditional T-cell subsets play a prominent role in MS immunopathology: Th17 cells, CD8+ effector T cells and CD4+CD25+ regulatory T cells. Multiple sclerosis (MS) is the most common demyelinating and an autoimmune disease of the central nervous system characterized by immune-mediated myelin and axonal damage, and chronic axonal loss attributable to the absence of myelin sheaths. So basically each anatomical structure has different functions to offer. Therefore, for instance the Purkinje cell with its huge dendrical tree acts as an integrator of many different signals. Additionally, a huge dendritic tree means that it has a lot of potential for many many connections to other neurons. Therefore, weak signals will maybe not even arrive at the soma since they decay with time. If the dendrites are long, it takes longer until they reach the soma. So the axon is responsible for the temporal delay of the signal conductance, similarily to the dendrite. If the trunk is long, then it will take longer for your friend to catch the ball, if the trunk is short, you might even be able to give it personally to your friend. Think of the signal as a ball that you want to give your friend you let it fall. A friend of yours is sitting on the grass next to the trees roots (which is the terminals in the neuron analogy). You are sitting in the area where all the branches come together and the trunk starts, this could be the same as the soma of a neuron since all dendrites come together. Different neuron structures change the way the signal is treated and conducted.
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